Biochemistry Science Fair Project
The development of a plant-based vaccine against SARS-CoV

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Project Information
Title: The development of a plant-based vaccine against SARS-CoV
Subject: Medicine / Biochemistry
Grade level: High School - Grades 10-12
Academic Level: Advanced
Project Type: Experimental
Cost: High
Second Place, Canada Wide Virtual Science Fair (2005)
Pfizer Canada Award of Excellence
First prize in intermediate life science division, University of Western Ontario

Affiliation: Canada Wide Virtual Science Fair
Description: The goal of this project is to produce a plant expression vector containing a synthetic DNA coding for an antigenic region of the SARS Spike protein fused to a bacterial gene encoding cholera toxin B subunit, and express it in transgenic tobacco plants. The results obtained from this project provide a foundation for the development of a low-cost, orally administered vaccine that can be used to prevent SARS infection.

Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus (SARS-CoV). There has been one near pandemic to date, between November 2002 and July 2003, with 8,096 known infected cases and 774 deaths (a case-fatality rate of 9.6%) worldwide being listed in the World Health Organization's (WHO) 21 April 2004 concluding report. Mortality by age group as of 8 May 2003 is below 1 percent for people aged 24 or younger, 6 percent for those 25 to 44, 15 percent in those 45 to 64 and more than 50 percent for those over 65. For comparison, the case fatality rate for influenza is usually around 0.6 percent (primarily among the elderly) but can rise as high as 33 percent in locally severe epidemics of new strains. The mortality rate of the primary viral pneumonia form is about 70 percent.

In December 2004 it was reported that Chinese researchers had produced a SARS vaccine. It has been tested on a group of 36 volunteers, 24 of whom developed antibodies against the virus.[First SARS vaccine trials a success China Daily January 15, 2005]

The emergence and identification of several common and rare human coronaviruses that cause severe lower respiratory tract infection argues for the judicious development of robust coronavirus vaccines and vector platforms. Currently, limited information is available on the correlates of protection against SARS-CoV and other severe lower respiratory tract human coronavirus infections, a clear priority for future research. Passive immunization has been successful in establishing protection from SARS-CoV suggesting an important role for neutralizing antibodies. One important property of future vaccine candidates is the ability to confer protection against multiple variant strains of SARS-CoV, especially in senescent populations that are most at risk for severe disease. Many vaccine candidates are capable of inducing humoral and cellular responses. The development of infectious clones for coronaviruses has facilitated the identification of attenuating mutations, deletions and recombinations which could ultimately result in live attenuated vaccine candidates. Stable vaccine platforms should be developed that allow for rapid intervention strategies against any future emergence coronaviruses. Vaccine correlates that enhance disease after challenge should be thoroughly investigated and mechanisms devised to circumvent vaccine-associated complications

Source: Wikipedia (All text is available under the terms of the Creative Commons Attribution-ShareAlike License)

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